From Worcester: Take Route I-290 to Route I-190 North to Exit 6 (Route 12, Sterling) to Route 62 East, Clinton. Follow the blue "H" (hospital) signs about 2.1 miles. At the flashing yellow light, take a left onto Highland Street. At the corner of Highland Street and Greeley Street, turn left. The hospital entrance is on the right.

From Route 495:

Berlin: Take Exit 26 (Route 62 West) to Clinton. Turn left at the end of the ramp. (Do not follow the blue hospital sign for Marlborough Hospital). Continue on Route 62 toward Sterling. Follow the blue "H" (hospital) signs approximately 6.3 miles to Main Street/Routes 62/70 in Clinton. Turn right onto Main Street. At third set of lights turn left to stay on Route 62/Brook Street. Follow about 0.3 miles, then turn right onto Greeley Street.The hospital's entrance is at the top of the hill on the right.

Bolton: Take Exit 27. Turn right off the exit onto Route 117/Main Street. Follow for 0.8 miles, and turn left onto Watoquadoc Road. Follow for approximately 3 miles. Watoquadoc Road becomes Bolton Road, then Water Street in Clinton. Stay on Water Street for 1 mile. At the second set of lights go right onto Route 62/70. At first set of lights, turn left to stay on Route 62/Brook Street. Follow about 0.3 miles, then turn right onto Greeley Street. The hospital's entrance is at the top of the hill on the right.

From Route 2: Take Exit 35 (Route 70, Lunenburg Road/Lancaster). Follow signs for Lancaster. At the junction of Route 117, turn left onto Main Street. In about 0.2 miles, turn right at the flashing yellow light to stay on Main Street. Follow Route 70 for approximately 2 miles. Take a slight right onto Sterling Road, then a left onto Parker Road, which leads to the hospital.

From Sterling and Princeton: Take Route 62 East toward Clinton. Follow the blue "H" (hospital) signs approximately 4.1 miles from Sterling center and 10.7 miles from Princeton center. At the flashing yellow light in Clinton, take a left onto Highland Street. At the corner of Highland Street and Greeley Street, turn left. The hospital entrance is on the right.